Brewer's helmet hit the turf on a sack by Oklahoma's Kenneth Murray early in the second quarter, and he was slow to get up. Two plays earlier, Brewer had lowered his shoulder at the end of a 7-yard run and knocked OU nickelback Brendan "Bookie" Radley-Hiles to the ground.
After that series, Brewer was briefly evaluated by the Baylor training staff, but he returned for another offensive series. After that possession, head referee Mike Defee asked coach Matt Rhule to have his training staff again examine Brewer.
"I didn't know anything," Rhule said after the game. "Mike Defee came over and said 'Coach, can you please look at Charlie? He just seems a little bit out of it.' Now, I had been talking to Charlie on the sidelines [before] and he didn't seem out of it to me, but I have a lot of respect for Mike Defee. And he said that, so I called over Matt [Kuehl, team trainer] and said 'Hey, they're saying on the field that they were concerned about Charlie.'"
Brewer took a big hit on a third-down play early in the second quarter against Oklahoma and appeared to be clearly shaken up and wobbly when he got to his feet to leave the field for the impending punt.
Despite this, Brewer immediately returned to the game on the next Baylor drive after being briefly examined on the sideline, though he still didn’t look right. According to ESPN’s Holly Rowe, Brewer was ultimately removed when head official Mike Defee intervened and essentially forced Baylor to take its quarterback to the locker room.